Nov
Vaping 101 Guides
What Is Nixodine? And Metatine? How They Differ From Nicotine
What is Nixodine? It’s an ingredient that some vapes use in place of nicotine, and Metatine is another one. Both are trade names. However, their makers tie both to the same chemical, 6-methyl nicotine. It’s a nicotine analog, which means a lab-made chemical built a lot like nicotine, but not the same molecule. Below, we first explain each name and then compare Nixodine vs nicotine. After that, we show where these vapes can ship and which ones we carry.
The short version
- Nixodine and Metatine are trade names for ingredients that vapes use in place of nicotine.
- Their makers link both names to 6-methyl nicotine, a nicotine analog.
- Nixodine vs nicotine comes down to the molecule, since the analog has one more carbon atom and two more hydrogen atoms.
- Synthetic nicotine is different. It’s real nicotine, just made in a lab.
- Some states, such as Indiana and North Carolina, ban nicotine analogs. So our checkout checks each order against your state’s rules.
What is Nixodine?
Nixodine is a trade name for an ingredient used in place of nicotine in vapes. The newest version, Nixodine-S, is a form of 6-methyl nicotine, its maker says. Its maker also says it doesn’t come from tobacco.
However, the name hasn’t always meant one formula. For example, researchers reported that earlier liquids sold as Nixodine listed a different main ingredient. So the name alone doesn’t tell you the exact formula inside a device. That’s why we list what each maker prints on the box, such as “5% Nixodine.”
Right now, we stock three Nixodine vapes: the Fifty Bar 20K, the RINNBAR 50K and the HorizonTech 100K. Each one is the Nixodine version of a device that also comes with nicotine.
What is Metatine?
Metatine is another trade name for an ingredient used in place of nicotine. Charlie’s Chalk Dust, the company behind PACHA MAMA, filed the Metatine trademark. In fact, the filing describes an “active chemical ingredient” for nicotine alternatives. Its maker has also said that SPREE BAR, a Metatine vape, uses 6-methyl nicotine.
In short, Metatine and Nixodine are two brand names tied to the same nicotine analog. For example, you’ll find Metatine in PACHA MAMA salts, the SBX 25K and the Juice Head Flex Freeze 50K.
Nixodine vs nicotine: what’s different?
Above all, the main difference is the molecule. Nicotine’s formula is C10H14N2, and federal rules define nicotine by that exact formula. 6-methyl nicotine, on the other hand, is C11H16N2. In other words, it’s nicotine’s structure with one extra methyl group. That small change makes it a different chemical, even though the two look alike on paper.
| Nixodine vs nicotine | Nicotine | Nixodine or Metatine |
|---|---|---|
| What it is | A chemical found in tobacco | A trade name for an ingredient used in place of nicotine |
| Molecule | C10H14N2 | 6-methyl nicotine (C11H16N2), the makers say |
| Made from | Tobacco, or made in a lab | Made in a lab, not from tobacco |
| Strength on the label | Percent or mg per mL | The same, such as 5% (50 mg/mL) |
| Shipping | Depends on your state’s vape rules | Fewer states, since some ban analogs |
So in a Nixodine vs nicotine comparison, the label math stays the same. For example, a 20 mL device at 5% holds 1,000 mg of the ingredient, whether that’s nicotine or an analog. Still, those numbers don’t tell you how the two compare, since they’re different chemicals. Also, our guide to how much nicotine is in a vape explains the label math in more detail.
Is Nixodine synthetic nicotine?
No. Synthetic nicotine is real nicotine, just made in a lab instead of taken from tobacco leaves. So it has the same chemical formula, C10H14N2. Nixodine and Metatine, by contrast, point to a nicotine analog, which is a different molecule.
Here’s what the FDA has said about each one. First, a federal law now covers tobacco products made with nicotine from any source, including synthetic nicotine. Second, the FDA told Reuters it was reviewing the available data on nicotine analogs. Meanwhile, some states have named analogs in their own laws.
Where these vapes can ship
Some states write nicotine analogs into their laws by name. For example, Indiana bans the sale of products with a nicotine analog, and North Carolina now does too. So we can’t ship Nixodine or Metatine vapes to either state.
Other states, however, allow only products on a state list, or only some flavors. In California, for instance, only a few tobacco flavors on the state’s list can ship, and nothing ships to San Francisco. These rules also change often.
That’s why our checkout checks each item against your state’s rules before it offers shipping. Each product page also lists the states it ships to. Or you can check your ZIP code before you order.
Nixodine and Metatine vapes we carry
Here are the Nixodine and Metatine vapes in stock now. Our three best sellers come first, and then the rest, including two new arrivals. Also, every product page lists the ingredient and the strength from the maker’s box.
Our best sellers
Our best-selling Metatine vape, rated by its maker for up to 50,000 puffs. You can also turn its ice and strength up or down.
Best for: Fruit and ice flavors, with the cooling set the way you like it.
Good to know: The strength control changes how much each puff delivers. However, the e-liquid itself stays at 5%.
Blueberry Watermelon Pomegranate PACHA MAMA Salt
Our best-selling PACHA MAMA salt: sweet blueberry, juicy watermelon and tart pomegranate, in a 50/50 VG/PG mix.
Best for: Refillable pod kits, since it comes in a bottle.
Good to know: It’s one of eight PACHA MAMA salts made with Metatine. The rest of the PACHA line, however, uses nicotine.
Our best-selling Nixodine vape in stock, with a dual mesh coil. The maker rates it for up to 20,000 puffs, and it comes in 11 flavors.
Best for: Tobacco fans in California, since Southern Tobacco and Gold Tobacco are on the state’s list.
Good to know: Only those two tobacco flavors can ship to California.
More to try
A Metatine vape from the company behind PACHA MAMA. It has three power modes, and the maker rates it for up to 25,000 puffs in Eco mode.
Best for: Picking your own power: Eco, Boost or X.
Good to know: Virginia Tobacco is the flavor on California’s list.
New in our shop, with 20 flavors and Eco and Boost modes. The maker rates it for up to 50,000 puffs in Eco mode.
Best for: Lots of choice, from fruit and ice to candy and mint.
Good to know: This is the Nixodine version. The regular version, on the other hand, uses nicotine.
Also new in our shop, and the biggest device here. It holds 40 mL, and the maker rates it for up to 100,000 puffs in Regular Mode.
Best for: The most puffs from one device.
Good to know: This is the Nixodine version. In contrast, the regular version uses nicotine.
Nixodine and Metatine FAQ
Is Nixodine nicotine?
No. Nixodine is a trade name for an ingredient used in place of nicotine. Its maker says the newest version is 6-methyl nicotine, a nicotine analog with a different molecule. For the full Nixodine vs nicotine breakdown, see the table above.
Is Metatine the same as Nixodine?
Not by name, since they’re trade names from different companies. However, both makers tie their ingredient to 6-methyl nicotine. Each product page also lists which one is inside that device.
What is synthetic nicotine?
It’s nicotine made in a lab instead of taken from tobacco, with the same chemical formula. Federal tobacco law covers it too, the FDA says. So it isn’t the same thing as Nixodine or Metatine.
Is Nixodine safer than nicotine?
We don’t make that claim, and you shouldn’t assume it. In fact, the FDA told Reuters that some emerging data show nicotine analogs “may be more potent than nicotine.” It also said more research is needed. For health facts from the CDC and FDA, see our guide to the negative effects of vaping.
What does 5% mean on a Nixodine or Metatine vape?
It means 50 mg of the ingredient in each mL of e-liquid, the same scale nicotine labels use. So a 20 mL device at 5% holds 1,000 mg. Still, those milligrams are the analog, not nicotine.
Why can’t I order these vapes to my state?
Some states ban products with a nicotine analog, such as Indiana and North Carolina. Others allow only listed products or some flavors. So our checkout only offers shipping where an item can go.
Do I need to be 21 to buy them?
Yes. We sell vapes only to adults 21 and older, and we check your age at checkout. That also includes Nixodine and Metatine vapes.
Shop Nixodine and Metatine vapes
Each product page lists the ingredient, the strength and the states it ships to.
This guide shares general facts. It is not medical or legal advice. Ingredient facts come from the makers’ labels, filings and public statements, and state rules change often. The FDA says to keep any e-liquid in its original bottle, out of reach of kids and pets. If someone swallows e-liquid, call Poison Control at 1-800-222-1222. You must be 21 or older to buy from us.